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Small bottles marked “smallpox” appeared in a vaccine research institution of Merck company in the United States

On November 16 local time, several US media quoted the US Centers for Disease Control and prevention as saying that vials marked with “smallpox” were found in the vaccine research institute of a Merck pharmaceutical factory on the outskirts of Philadelphia, Pennsylvania.
The U.S. Centers for Disease Control and Prevention said the vial marked “smallpox” was accidentally found by a staff member of the agency while cleaning the refrigerator. At that time, the staff member was wearing gloves and masks. The Centers for Disease Control and prevention did not disclose other information.
It is reported that because the smallpox virus is too dangerous, only two laboratories in the world are authorized to store samples, one in Russia and the other is a subsidiary of the CDC in Atlanta.
It is reported that the CDC, its government partners and law enforcement agencies are investigating the matter. The Centers for Disease Control and prevention stressed that there was no indication that anyone had touched the vials.
The Department of homeland security, the National Institutes of health and Merck did not respond to requests for comment.
Merck is called Merck sharp & Dohme (MSD) in countries outside the United States and Canada. It is not only an American pharmaceutical enterprise, but also one of the largest pharmaceutical enterprises in the world. Merck is headquartered in Kenilworth, New Jersey.

Click Therapeutics

In less than a year since the last debt financing, click therapeutics, a digital therapy start-up, recently announced that it had obtained a round B financing of US $52 million.
This round of financing is jointly led by new investors h.i.g. biohealth partners and accelmed partners II, with the participation of health catalyst capital, redemption partners and a top biotechnology hedge fund, as well as existing investment institutions Sanofi ventures, K2 healthventures, hikma ventures and ridgetop health.
David benshoof Klein, CEO and co-founder of the company, described this round of financing as an “important milestone” and revealed that this round of funds will be used to accelerate the development and commercialization of click’s internal prescription digital treatment pipeline and improve its platform capacity.
The New York based startup, founded in April 2012, is committed to providing patients with digital prescription treatment solutions through the development and commercialization of software.
Click therapeutics is literally translated into Chinese as “click therapy”. The company name is very vivid and very consistent with the product – patients and doctors interact by clicking on the application on the mobile phone screen, and then use digital therapy to treat diseases.

The Side Effects of Sleeping Pills

A third to half of Americans suffer from insomnia and complain about lack of sleep. Maybe you’re one of them. If so, you may consider taking sleeping pills.
Sleeping pills can relieve your sleep problems in the short term. But it’s important to know all about sleeping pills. This includes understanding the side effects of sleeping pills. When you do this, you can avoid abusing these sedatives.
What are the side effects of sleeping pills?
Like most drugs, sleeping pills have side effects. However, before you try, you don’t know whether taking some sleeping pills will have side effects.
If you have asthma or other health conditions, your doctor may tell you some side effects. Sleeping pills interfere with normal breathing and may be dangerous for people with chronic lung diseases such as asthma, emphysema or chronic obstructive pulmonary disease (COPD).
Common side effects of prescription sleeping pills such as sleeping pills, Halcion, lunesta, rozerem and Sonata include:
Burning or tingling of hands, arms, feet or legs
Appetite change
constipation
diarrhea
Balance problem
dizzy
daytime sleepiness
Dry mouth
coal gas
headache
Heartburn
the second day
Slow thinking or attention or memory problems
stomachache
Uncontrollable shaking of a part of the body
An unusual dream
weakness
It is important to be aware of the possible side effects of sleeping pills so that you can stop taking sleeping pills and call your doctor immediately to avoid more serious health problems.

What we need to know ahout the COVID-19 Delta variant:

What do you know?
It spreads very fast. As of August 4, 2021, delta variants have covered more than 130 countries. In many countries, the number of coronavirus diseases has exceeded α The variation, including the United States, is considered to be 55% to 90% easier to spread than the previous covid-19 variation. Experts believe that the infectivity of the delta is 30% to 100% higher than that of alpha.
Researchers are still not sure why the delta variant is more likely to spread than other variants. They believe that changes in the mutant protein may make it easier to enter human cells. Another early study showed that the mutation of delta variant may help it better fuse with human cells after attaching itself. If it can easily mix with your cells, it can infect more cells and overwhelm your immune system.
It seems to affect young people more often. In the UK, studies have shown that children and adults under the age of 50 are 2.5 times more likely to be infected.
Symptoms seem to be more severe and occur faster. If the patient has delta variation, he is more likely to be hospitalized. Studies have shown that its risk of hospitalization is almost twice that of alpha variation.
In China, doctors say patients with delta mutation are more serious than those they treated in the early stage of the pandemic. Their condition seems to be declining faster.
Zoikovi 2019 coronavirus disease research, an application that allows people to track symptoms, shows that covid-19 symptoms in the UK may change with the spread of delta variants.
The main symptoms reported on the application include:
headache
sore throat
runny nose
fever
Cough is becoming less and less common, and loss of smell is no longer among the top ten common symptoms. The researchers worry that people may mistake the symptoms for a bad cold, so as to avoid isolation and lead to the spread of the mutant virus.
How to protect yourself
Vaccination is your best choice. The report showed that two doses of Pfizer biontech vaccine had 79% protective effect on Delta variant infection. If infected, it seems to have a 96% effect on hospitalization.
Due to delta variation, the success rate of two doses of AstraZeneca vaccine in stopping hospitalization was 92%. No deaths were reported in the vaccinated population.

Bristol Myers Squibb cooperated with Exscientia to develop immunomodulatory candidate drugs using AI

Recently, Bristol Myers Squibb (BMS) announced the application of an immunomodulatory candidate drug developed by exscientia.
Exscientia, an AI driven pharmaceutical technology company, has designed three drugs in phase I human clinical trials. At present, exscientia has offices in Oxford, Miami, Vienna and Osaka. On April 27, exscientia announced that it had completed the round D financing of US $225 million led by Softbank vision fund. In addition, Softbank vision fund also provided another US $300 million investment commitment, and exscientia decided whether to inject capital at its own discretion.
It is understood that exscientia has two cooperation with Bristol Myers Squibb, focusing on multiple treatment fields, including oncology and immunology. In May this year, the two sides reached a cooperation agreement with a potential value of more than $1.2 billion.
The licensed candidate drug targets a key immune kinase. Due to the need to combine selectivity and overall drug characteristics, it has been proved that this immune kinase is difficult to target.
In order to design new drug candidates that can overcome these problems, exscientia uses its end-to-end platform to promote the discovery process, including artificial intelligence driven design, structural biology, chemistry, pharmacology and later preclinical research.
Exscientia’s precision design approach focuses on simultaneously addressing parameters important to the overall therapeutic performance of the target, such as efficacy, selectivity, safety and physicochemical properties. Its AI platform is suitable for solving multi-objective design problems, so as to find new drug candidates with excellent characteristics efficiently and quickly.
Andrew Hopkins, CEO of exscientia, commented: “we focus on designing accurate engineering drugs for challenging drug product characteristics with ‘patient first’ AI technology, and the efficiency of our platform is very high. This candidate drug molecule is the 150th new compound designed and tested, which was identified within 11 months after we started drug design. Through cooperation with Bristol Myers Squibb, coupled with its world-class clinical research and commercialization capabilities, we look forward to advancing the candidate drug to the next stage of development. “
Rupert Vessey, a research and development president of Bristol Myers Squibb, said: “we are pleased to obtain the license of the first candidate drug for strategic cooperation with exscientia. AI learning will continue to play an important role in drug discovery, and exscientia has provided a promising development direction in the field of immunology. We look forward to working together to further promote this candidate drug and bring more benefits to patients. “
It is understood that Bristol Myers Squibb will be responsible for the clinical and commercial development of candidate drugs. Under the terms of the agreement, exscientia will receive an option exercise fee of US $20 million, including the possibility of achieving additional development milestones and royalties for the net sales of any commercial products.

What are the health care products that can’t be eaten by children

Although some health products play a great role in promoting children’s body and maintaining children’s health, this does not mean that children are suitable for all health products. If you take it blindly to children, it may have the opposite effect and have an adverse impact on the baby’s growth, development and health. Children should not abuse health care products. According to expert research, health care products containing the following ingredients are not suitable for babies:

  1. Ginseng
    Ginseng is one of the common supplements, but it is not suitable for children, because it contains some substances that can accelerate children’s gonadal hormone secretion, such as ginseng, ginsenoside, etc., which are more likely to cause children to precocious puberty or disorder of the body system, which is very unfavorable to children’s physical and mental development and health.
  2. Royal jelly
    The main components of royal jelly are inorganic salts, amino acids, vitamins, hormones and other substances. The composition is complex. Although taking this supplement will not cause too many negative effects for adults, it may cause precocious puberty for children.
  3. Others
    Although some traditional Chinese medicines with bird’s nest, sex hormones and other substances have the effect of regulating the body, they should not be used for children, because these traditional Chinese medicines may also make children precocious puberty.
Softbank invested US $5 billion in Roche, a Swiss pharmaceutical giant, and became a major shareholder

People familiar with the matter said that Softbank group has quietly established a US $5 billion stake in Roche, Switzerland, betting on the company’s strategy of using data to develop drugs and become one of Roche’s major shareholders. Softbank believes that the value of Roche’s Genentech is seriously underestimated, and the department focuses on data-based drug discovery and development. At present, Roche is developing a new pill for the new crown virus and is studying a disease treatment for Alzheimer’s disease. In June this year, the United States approved aduhelm, a drug of Biogen company for the treatment of Alzheimer’s disease, which is a positive signal for Roche.

Novartis pharmaceutical approved hypertension indications

Novartis pharmaceutical announced that the State Drug Administration approved nuoxintol on June 1 ®( Salkubatrol (valsartan) is used to treat essential hypertension. As norcintal ®( Following the listing of indications for heart failure in 2017, the second indication approved in China, this approval marks the breakthrough of new drugs in the field of hypertension treatment in China for more than 10 years, and is expected to lead the management mode of hypertension treatment from simple hypotension to the whole process risk control of cardiovascular events.
Sacubatrovalsartan is the world’s first angiotensin receptor enkephalinase inhibitor (Arni). The results of a phase III clinical study led by Professor Huo Yong, vice chairman of China Cardiovascular Health Alliance and the first hospital of Peking University, show that after 8 weeks of treatment, the antihypertensive effect of sakubatrovalsartan is significantly better than olmesartan (control drug), which has the best antihypertensive effect among ARB drugs, and can significantly improve the compliance rate of blood pressure. A total of 1438 Asian patients with mild to moderate essential hypertension aged 18 and over (sitting systolic blood pressure ≥ 140 to < 180 mm Hg) were included in the study, of which 85% were Chinese patients. In addition, many studies have also shown that whether the blood pressure level of patients with hypertension is high or low, whether they are combined with risk factors or heart and kidney damage, sacubatrovalsartan shows universal antihypertensive effect [1].
Hypertension is the primary risk factor for inducing cardiovascular events. As a large country of hypertension, China has 245 million adult patients with hypertension [2], but the standard rate of blood pressure is only 15.3% [3]. The damage of heart, kidney, blood vessels and other organs caused by hypertension significantly increases the risk of cardiovascular death and keeps the disability and death rate related to hypertension high. Professor Huo Yong said: “the management of hypertension in China is facing multiple challenges, such as low compliance rate, high proportion of complications, aggravation of target organ damage and so on. In recent years, the treatment of hypertension began to focus on the treatment strategy based on hypotension, reducing the risk of cardiovascular events and improving the prognosis of patients. In terms of blood pressure reduction, sakubatrovalsartan shows the characteristics of large reduction, rapid onset and 24-hour pressure control. At the same time, it also shows superior protective effects on organs such as heart, kidney and blood vessels. It can block the chain of cardiovascular events in multiple ways and reduce the risk of cardiovascular events. The application of salkubatrol and Valsartan in the field of hypertension will further optimize the existing treatment scheme, which is of milestone significance to the management of hypertension. “

Tips for choosing calcium tablets

1、 Don’t follow advertising. Increase their health care knowledge and correctly understand calcium supplementation. Calcium production enterprises often take stars as the precursor to attract consumers. In this regard, we should make a choice according to our own needs and not be confused by various loud calcium supplement commodity names. Remember that such commercial terms are pure speculation and do not exist in the field of nutrition.
2、 Don’t listen to the exaggerated propaganda of some calcium products. For example, some advertisements call “good deposition and fast absorption”, which makes people mistakenly believe that the absorption of calcium by the human body is a simple process. In fact, calcium enters the human body first into the blood, then forms calcium containing cells, and then penetrates the outermost hard layer of the bone through a complex change process and is fixed into the inner bone.
Another advertisement claims that its product “particles are several times smaller than ordinary products”. In fact, the particle size is only a physical change, which can not essentially improve the absorption rate of calcium by the human body; The absorption rate of calcium in calcium supplement products is only about 30%. In fact, there is no so-called “95%” absorption rate.
3、 Try to improve the diet structure to obtain sufficient calcium from natural foods. In the daily food of the family, milk, cheese, eggs, bean products, kelp, laver, shrimp skin, sesame, hawthorn, sea fish, vegetables, etc. contain more calcium, especially milk. Every 100 grams of fresh milk contains 120 mg of calcium. If each person drinks 250 grams of milk every day, he can provide 300 mg of calcium.
If you drink 500 grams of milk every day, you can supply 600 mg of calcium; In addition, about 300 mg of calcium supplied by other foods in the diet can fully meet the needs of human body for calcium. It is worth noting that when eating these calcium rich foods, we should avoid eating too many foods rich in phosphate, oxalic acid and protein, so as not to affect the absorption of calcium.
4、 To detect the content of calcium, you should go to a regular hospital. The “single photon bone mineral density tester” placed in stores and pharmacies can only measure the ulna and radius of the arm, and the loss of calcium is mainly harmful to the calcium deficiency of the lumbar spine and crotch, so this test is inaccurate. Moreover, such instruments are radioactive sources, and their radiation will affect the body.
5、 Calcium products are not the more expensive the better, they should be selected according to their own needs. There is no great difference in the quality of calcium products circulating in the market. Moreover, different calcium products are suitable for different people. Calcium carbonate has high net calcium content and high absorption rate. It is a traditional calcium supplement, but it is not suitable for people with gastric acid deficiency; Calcium phosphate contains high phosphorus, but it is not suitable for patients with chronic renal insufficiency.
6、 Calcium supplement is not the more the better. The important thing is to see absorption. When taking more than 200 mg of elemental calcium each time, the absorption rate will be reduced.

Research shows that the number of antibodies produced by injection of Moderna vaccine is more than twice that of Pfizer

A study showed that the number of antibodies produced by the injection of Moderna new crown vaccine was more than twice that of PFE. Us new crown vaccine.
The study was conducted among 2500 workers who were vaccinated with Moderna and Pfizer respectively. The study found that after two doses of vaccine injection, the average antibody per milliliter of workers who injected the former reached 2881 units, while the latter only had 1108 units.
Several possible reasons for this difference are:

  1. The active ingredient of Moderna vaccine reaches 100 μ g, which is higher than that of Pfizer vaccine, which is only 30 μ G.
  2. The interval of Moderna vaccination was longer, 4 weeks. Pfizer vaccine takes only 3 weeks.
    An assessment shows that Moderna vaccine can reduce COVID-19’s breakthrough infection risk by two times compared with Pfizer vaccine.
    As of press time, Moderna shares fell 0.85% and Pfizer shares rose 0.15% after hours.