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Professional articles
Small bottles marked “smallpox” appeared in a vaccine research institution of Merck company in the United States

On November 16 local time, several US media quoted the US Centers for Disease Control and prevention as saying that vials marked with “smallpox” were found in the vaccine research institute of a Merck pharmaceutical factory on the outskirts of Philadelphia, Pennsylvania.
The U.S. Centers for Disease Control and Prevention said the vial marked “smallpox” was accidentally found by a staff member of the agency while cleaning the refrigerator. At that time, the staff member was wearing gloves and masks. The Centers for Disease Control and prevention did not disclose other information.
It is reported that because the smallpox virus is too dangerous, only two laboratories in the world are authorized to store samples, one in Russia and the other is a subsidiary of the CDC in Atlanta.
It is reported that the CDC, its government partners and law enforcement agencies are investigating the matter. The Centers for Disease Control and prevention stressed that there was no indication that anyone had touched the vials.
The Department of homeland security, the National Institutes of health and Merck did not respond to requests for comment.
Merck is called Merck sharp & Dohme (MSD) in countries outside the United States and Canada. It is not only an American pharmaceutical enterprise, but also one of the largest pharmaceutical enterprises in the world. Merck is headquartered in Kenilworth, New Jersey.

Click Therapeutics

In less than a year since the last debt financing, click therapeutics, a digital therapy start-up, recently announced that it had obtained a round B financing of US $52 million.
This round of financing is jointly led by new investors h.i.g. biohealth partners and accelmed partners II, with the participation of health catalyst capital, redemption partners and a top biotechnology hedge fund, as well as existing investment institutions Sanofi ventures, K2 healthventures, hikma ventures and ridgetop health.
David benshoof Klein, CEO and co-founder of the company, described this round of financing as an “important milestone” and revealed that this round of funds will be used to accelerate the development and commercialization of click’s internal prescription digital treatment pipeline and improve its platform capacity.
The New York based startup, founded in April 2012, is committed to providing patients with digital prescription treatment solutions through the development and commercialization of software.
Click therapeutics is literally translated into Chinese as “click therapy”. The company name is very vivid and very consistent with the product – patients and doctors interact by clicking on the application on the mobile phone screen, and then use digital therapy to treat diseases.

The Side Effects of Sleeping Pills

A third to half of Americans suffer from insomnia and complain about lack of sleep. Maybe you’re one of them. If so, you may consider taking sleeping pills.
Sleeping pills can relieve your sleep problems in the short term. But it’s important to know all about sleeping pills. This includes understanding the side effects of sleeping pills. When you do this, you can avoid abusing these sedatives.
What are the side effects of sleeping pills?
Like most drugs, sleeping pills have side effects. However, before you try, you don’t know whether taking some sleeping pills will have side effects.
If you have asthma or other health conditions, your doctor may tell you some side effects. Sleeping pills interfere with normal breathing and may be dangerous for people with chronic lung diseases such as asthma, emphysema or chronic obstructive pulmonary disease (COPD).
Common side effects of prescription sleeping pills such as sleeping pills, Halcion, lunesta, rozerem and Sonata include:
Burning or tingling of hands, arms, feet or legs
Appetite change
constipation
diarrhea
Balance problem
dizzy
daytime sleepiness
Dry mouth
coal gas
headache
Heartburn
the second day
Slow thinking or attention or memory problems
stomachache
Uncontrollable shaking of a part of the body
An unusual dream
weakness
It is important to be aware of the possible side effects of sleeping pills so that you can stop taking sleeping pills and call your doctor immediately to avoid more serious health problems.

What we need to know ahout the COVID-19 Delta variant:

What do you know?
It spreads very fast. As of August 4, 2021, delta variants have covered more than 130 countries. In many countries, the number of coronavirus diseases has exceeded α The variation, including the United States, is considered to be 55% to 90% easier to spread than the previous covid-19 variation. Experts believe that the infectivity of the delta is 30% to 100% higher than that of alpha.
Researchers are still not sure why the delta variant is more likely to spread than other variants. They believe that changes in the mutant protein may make it easier to enter human cells. Another early study showed that the mutation of delta variant may help it better fuse with human cells after attaching itself. If it can easily mix with your cells, it can infect more cells and overwhelm your immune system.
It seems to affect young people more often. In the UK, studies have shown that children and adults under the age of 50 are 2.5 times more likely to be infected.
Symptoms seem to be more severe and occur faster. If the patient has delta variation, he is more likely to be hospitalized. Studies have shown that its risk of hospitalization is almost twice that of alpha variation.
In China, doctors say patients with delta mutation are more serious than those they treated in the early stage of the pandemic. Their condition seems to be declining faster.
Zoikovi 2019 coronavirus disease research, an application that allows people to track symptoms, shows that covid-19 symptoms in the UK may change with the spread of delta variants.
The main symptoms reported on the application include:
headache
sore throat
runny nose
fever
Cough is becoming less and less common, and loss of smell is no longer among the top ten common symptoms. The researchers worry that people may mistake the symptoms for a bad cold, so as to avoid isolation and lead to the spread of the mutant virus.
How to protect yourself
Vaccination is your best choice. The report showed that two doses of Pfizer biontech vaccine had 79% protective effect on Delta variant infection. If infected, it seems to have a 96% effect on hospitalization.
Due to delta variation, the success rate of two doses of AstraZeneca vaccine in stopping hospitalization was 92%. No deaths were reported in the vaccinated population.

Bristol Myers Squibb cooperated with Exscientia to develop immunomodulatory candidate drugs using AI

Recently, Bristol Myers Squibb (BMS) announced the application of an immunomodulatory candidate drug developed by exscientia.
Exscientia, an AI driven pharmaceutical technology company, has designed three drugs in phase I human clinical trials. At present, exscientia has offices in Oxford, Miami, Vienna and Osaka. On April 27, exscientia announced that it had completed the round D financing of US $225 million led by Softbank vision fund. In addition, Softbank vision fund also provided another US $300 million investment commitment, and exscientia decided whether to inject capital at its own discretion.
It is understood that exscientia has two cooperation with Bristol Myers Squibb, focusing on multiple treatment fields, including oncology and immunology. In May this year, the two sides reached a cooperation agreement with a potential value of more than $1.2 billion.
The licensed candidate drug targets a key immune kinase. Due to the need to combine selectivity and overall drug characteristics, it has been proved that this immune kinase is difficult to target.
In order to design new drug candidates that can overcome these problems, exscientia uses its end-to-end platform to promote the discovery process, including artificial intelligence driven design, structural biology, chemistry, pharmacology and later preclinical research.
Exscientia’s precision design approach focuses on simultaneously addressing parameters important to the overall therapeutic performance of the target, such as efficacy, selectivity, safety and physicochemical properties. Its AI platform is suitable for solving multi-objective design problems, so as to find new drug candidates with excellent characteristics efficiently and quickly.
Andrew Hopkins, CEO of exscientia, commented: “we focus on designing accurate engineering drugs for challenging drug product characteristics with ‘patient first’ AI technology, and the efficiency of our platform is very high. This candidate drug molecule is the 150th new compound designed and tested, which was identified within 11 months after we started drug design. Through cooperation with Bristol Myers Squibb, coupled with its world-class clinical research and commercialization capabilities, we look forward to advancing the candidate drug to the next stage of development. “
Rupert Vessey, a research and development president of Bristol Myers Squibb, said: “we are pleased to obtain the license of the first candidate drug for strategic cooperation with exscientia. AI learning will continue to play an important role in drug discovery, and exscientia has provided a promising development direction in the field of immunology. We look forward to working together to further promote this candidate drug and bring more benefits to patients. “
It is understood that Bristol Myers Squibb will be responsible for the clinical and commercial development of candidate drugs. Under the terms of the agreement, exscientia will receive an option exercise fee of US $20 million, including the possibility of achieving additional development milestones and royalties for the net sales of any commercial products.

What are the health care products that can’t be eaten by children

Although some health products play a great role in promoting children’s body and maintaining children’s health, this does not mean that children are suitable for all health products. If you take it blindly to children, it may have the opposite effect and have an adverse impact on the baby’s growth, development and health. Children should not abuse health care products. According to expert research, health care products containing the following ingredients are not suitable for babies:

  1. Ginseng
    Ginseng is one of the common supplements, but it is not suitable for children, because it contains some substances that can accelerate children’s gonadal hormone secretion, such as ginseng, ginsenoside, etc., which are more likely to cause children to precocious puberty or disorder of the body system, which is very unfavorable to children’s physical and mental development and health.
  2. Royal jelly
    The main components of royal jelly are inorganic salts, amino acids, vitamins, hormones and other substances. The composition is complex. Although taking this supplement will not cause too many negative effects for adults, it may cause precocious puberty for children.
  3. Others
    Although some traditional Chinese medicines with bird’s nest, sex hormones and other substances have the effect of regulating the body, they should not be used for children, because these traditional Chinese medicines may also make children precocious puberty.